The Link Between Metabolic Syndrome and Chronic Kidney Disease: Focus on Diagnosis and Therapeutics, volume II

Book excerpt: Metabolic syndrome (MetS), including obesity, hyperglycemia, hyperlipidemia, hyperinsulinemia, are associated with disturbed energy homeostasis, limited whole-body insulin sensitivity, and an increased risk of cardiovascular and chronic kidney disease (CKD). The prospective and cross-sectional studies have shown a close association between the MetS and CKD. Chronic inflammation and vascular dysfunction are two key MetS-related etiological factors for renal injury. CKD is characterized by mitochondrial dysfunction, oxidative stress, and aberrant autophagy at the cellular level, which is also typical of metabolic disorders. However, the relationship and mechanism between metabolic disease and chronic kidney dysfunction still call for deeper understanding. This Research Topic aims to gather both Reviews and Original Research articles focused on discovering the truth behind the phenomenon that glucose and lipid metabolic disorders and obesity have important public health implications in terms of individuals with CKD. The studies covering new insights to determine the link between MetS-related immunity response and renal dysfunction will also be considered.