The Albino Mouse Visual System
Author | : Punita Bhansali |
Publisher | : |
Total Pages | : |
Release | : 2013 |
ISBN-10 | : OCLC:1004785249 |
ISBN-13 | : |
Rating | : 4/5 (49 Downloads) |
Book excerpt: Thus, this thesis provides a link between neurogenesis and specification in the albino retina. To further elucidate the role of melanin synthesis in VT RGC specification, I tested the effects of L-Dopa treatment of embryonic mice on retinal development and found that L-Dopa ameliorated the defects associated with the reduced ipsilateral projection in the albino mouse by regulating cell proliferation and production. The studies in this thesis contribute to an understanding of the mechanism that underlies the disruption of binocular pathways in the albino visual system, and should illuminate how the pigment pathway in the RPE contributes to development of the neural retina in wild type mice.