Multi-modality Imaging of Atherosclerotic Plaque Using Optical Coherence Tomography
Author | : Edouard Gerbaud |
Publisher | : |
Total Pages | : 0 |
Release | : 2016 |
ISBN-10 | : OCLC:962377968 |
ISBN-13 | : |
Rating | : 4/5 (68 Downloads) |
Book excerpt: Intravascular imaging technologies i.e. IVUS and IV-OCT are valuable tools for interventionguidance and diagnostic plaque imaging.Chapter 1 introduces the drawbacks of coronary angiography in the clinical practice. In severalcircumstances, IVUS and IV-OCT have clearly an additional value when they are used as adiagnosis tool in case of angiographic ambiguities. We recently reported the first observationusing IV-OCT to describe a coronary dissection of a septal perforating branch causing AMI.Chapter 2 focuses on the inter-institute reliability of IV-OCT to determine qualitative andquantitative parameters of atherosclerotic plaque. The purpose of our study was to investigatefurther inter- and intra-observer reproducibility, the inter-institute variability for IV-OCT (OFDI)quantitative and qualitative measurements vs. IVUS measurements using publishedconsensus document definitions. In our work, we observed that in the measurement of lumenCSA, maximum and minimum lumen diameters, stent CSA, maximum and minimum stentdiameters by analysts from 2 different laboratories, inter-institute reproducibility of OFDI wasfound to be more consistent than IVUS.Chapter 3 present 2 new robust hybrid intravascular imaging technologies developed in Dr.Tearney's laboratory i.e. OFDI-NIRS and OFDI-NIRAF, which may offer supplementary criteriafor plaque vulnerability. First-in-human OFDI-NIRS imaging procedures are anticipated in thenear future. First-in-human OFDI-NIRAF imaging procedures have been performed in a firstpioneering series of 12 stable patients between July 2014 and January 2015. Findings of thispilot study showed that NIRAF was focally elevated in plaque locations where most high-riskmorphologic phenotypes were evident. The biochemical substrates of the NIRAF signal stillhave to be elucidated.