Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
Author | : Yvonne Will |
Publisher | : John Wiley & Sons |
Total Pages | : 816 |
Release | : 2018-03-23 |
ISBN-10 | : 9781119329749 |
ISBN-13 | : 1119329744 |
Rating | : 4/5 (49 Downloads) |
Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria