Programming HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation
Author | : Rachel Yehuda |
Publisher | : Frontiers Media SA |
Total Pages | : 141 |
Release | : 2015-03-16 |
ISBN-10 | : 9782889194810 |
ISBN-13 | : 2889194817 |
Rating | : 4/5 (10 Downloads) |
Book excerpt: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.