Measurement of CYP 3A4 and P-GP Activity in Vivo Using Dynamic Breath and Urine Analysis
Author | : Wim Lemahieu |
Publisher | : Leuven University Press |
Total Pages | : 200 |
Release | : 2005 |
ISBN-10 | : 9058674509 |
ISBN-13 | : 9789058674500 |
Rating | : 4/5 (09 Downloads) |
Book excerpt: This is a Ph.D. dissertation. Contents include: General introduction, Measurement of intestinal CYP3A4 and P-Glycoprotein activity by a combined oral and intravenous 14C-Erythromycin breath and urine test, Alterations of CYP3A4 and P-Glycoprotein activity in vivo with time in renal graft recipients, CYP3A4 and P-Glycoprotein activity in healthy controls and transplant patients on cyclosporine vs. Tacrolimus vs. Sirolimus, Impact of gastric acid suppressants on cytochrome P450 3A4 and P-Glycoprotein: consequences for FK506 assimilation, Diarrhoea after transplantation: impact on cytochrome P4503A4/P-Glycoprotein and assimilation of calcineurin inhibitors, Discussion.